LSD and the Head Twitch Response
The Hamilton Morris Podcast
In this episode Jason Wallach and I discuss the strange origin of the head twitch response and how it became the most important behavioral correlate for 5HT2A agonism in non-human animals. Paper: Permanent alteration of behavior in mice by chemical and psychological meansTop Tree Herbs Kratom Tea BagsTop Tree Herbs is the first kratom tea bag companyLucy Tobacco Free NicotineLucy's mission is to reduce tobacco-related harm to zero.Mind Cure HealthA Full Cycle of Mental Wellness From Resea...
Transcript
Summary
The transcript is a discussion of the 1956 paper on LSD and indole that helped establish the head twitch response as a key rodent assay for psychedelics. It also critiques animal models in psychiatry, debates reproducibility and mechanism, and argues that psychedelic experience and 5-HT2A signaling are central to therapeutic effects.
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