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The Hamilton Morris Podcast is a series focused on the chemistry, history, and cultural impact of psychoactive substances
…I went back through it, I realized that it was Methelman modifying a process that was popularized by a different chemist named Ritter, who was then popularizing a synthesis that I believe was first featured by Strike in Total Synthesis 2. And I imagine…
…was only ever the two. I did the benzoquinone whacker on the Brazilian sassafras to get the MDPTP. And then I did the Ritter nitromethane aluminum amination from the strike book because, remember, I had read the strike book, you know, 30 times in a row.…
…that had the least potential for explosion, the least stress when trying to get the chemicals. Everything just pointed to that Ritter synth. Who is it that first developed the in-situ generation of methylamine by using nitromethane with the amalgam? I had…
…be on the case when I was talking to you, but I can't find it right now. But basically, that was a guy named Ritter who was on the hive. And of course, he was using a write-up from the literature, from the academic literature. He'd found something…
…because they just weren't very good writers and they weren't including details in their write-ups. So as I did my first, you know, Ritter... I was like, oh, well, why didn't he say that, you know, this happens and, you know, that it's the drip rate with…
…but I, you know, it's been 25 years, so I can't remember all the scales, but I, I got, I know I got more than one, uh, Ritter emanation out of, uh, out of a whacker for sure. Like I think I want to say three, I could get three and a little bit…
…them or whether I just refined them a little bit. But one thing that sticks out in my mind was, I think in the Ritter preparation of the aluminum and the Ritter in the amination, the reductive amination, it was... just kind of said to just get some…
…them a little bit. But one thing that sticks out in my mind was, I think in the Ritter preparation of the aluminum and the Ritter in the amination, the reductive amination, it was... just kind of said to just get some foil and just kind of rip it up…