…and so I kept running the assays and trying to figure out what I've done wrong to get these results. Then later, Brian Roth came along and characterized it. And yep, that's what it was. I mean, Salvinorin A is absolutely really the most potent natural…

…ever discovered, including LSD. And I was getting like picomolar inhibition constants, and it was crazy. So you discovered this before Roth? You discovered the kappa agonist activity before Roth and just didn't believe it? I didn't believe it, yeah. And it…

…like picomolar inhibition constants, and it was crazy. So you discovered this before Roth? You discovered the kappa agonist activity before Roth and just didn't believe it? I didn't believe it, yeah. And it was on crude extracts, and I kept running it,…

…interesting lesson because that was also before Siebert had done the self-experiment with Salvinorin A, right? So that maybe helped Brian Roth a little bit because he already knew that the compound in question was amazingly potent and active at sub-milligram…

…and dopamine receptors and this and that, all at various affinities. But Kappa, the Salvadoran A hits only the Kappa receptor. And Brian Roth told me, he said, you know, if I had set out to design a molecule that was a selective Kappa opiate receptor,…

…Peru three or four, four or five times to do collections on their nickel and brought these samples back. And I connected with Brian Roth, and they did all the receptor stuff at that time. They had all of this set up. They ran the NIMH psychoactive drug…

…Yeah, no, I'm very excited. And it was cool to see the ultra LSD process validated with the melatonin receptor ligands that Roth was working on to see that that technique really actually was able to produce some results. Oh, it absolutely works. I've…

…large docking campaigns. that can then actually be experimentally validated. And there's been huge improvements in that space, even by, by Roth and others. Well, given that this has been around for a little while and that there's been success at other…

…talk about this like the gray market doesn't exist anymore when it very much does. So if you or I or anyone, Brian Roth, David Olson, anyone, Mike Cunningham, if any of those people come up with something good. the gray market is still there. Nothing…